Two of the American League’s top pitchers take the mound on the road, while the Rockies try to knock around the Mets’ ace.

Colliding in the Junior Circuit . . .

Zack Greinke (10-6, 2.04 ERA) will try to edge his ERA back under 2.00 on Wednesday night when he takes to the mound in Baltimore against the Orioles and Chris Tillman (0-0, 0.00 ERA). Kansas City is 0-4 in Greinke’s last four trips to the mound, but the righthander has surrendered just seven earned runs over 26 innings pitched in those outings. Righthander Tillman will be making his Major League debut for the Orioles; he was 8-6 with a 2.70 ERA with Triple-A Norfolk.

Also on the American League schedule for Wednesday: Cleveland at the Angels, the Yankees at Tampa Bay, Oakland at Boston, Detroit at Texas, the White Sox at Minnesota, and Toronto at Seattle. Barring a trade, the Blue Jays will send ace Roy Halladay (11-3, 2.62 ERA) to the hill in that contest; righthander Halladay took a no-decision vs. the Rays last time out, giving up one earned run over nine innings of work. The Mariners counter with Ryan Rowland-Smith (0-1, 3.48 ERA).

Clashing in the Senior Circuit . . .

Clayton Kershaw (8-5, 2.96 ERA) will match up against Joel Pineiro (9-9, 2.95 ERA) on Wednesday night as the Dodgers continue their series against the Cardinals. Lefthander Kershaw, also the subject of trade rumors, was stuck with a no-decision against the Marlins last time out despite giving up just two earned runs over six innings. Righthander Pineiro has won each of his last three starts for the Cardinals, giving up just two earned runs over those 22 innings of work.

Making up the rest of the National League slate for Wednesday: Houston at the Cubs, Pittsburgh at San Francisco, San Diego at Cincinnati, Atlanta at Florida, Washington at Milwaukee, Philadelphia at Arizona, and Colorado at the Mets. Jason Hammel (5-5, 4.28 ERA) will get the ball for the Rockies in that last matchup, while New York will counter with Johan Santana (11-8, 3.12 ERA). Santana lost to the Astros last time out, surrendering five runs over 6 2-3 innings.

Rounding out the Roundup . . .

Finally, there’s just one game on the WNBA schedule for Wednesday, with Los Angeles at Chicago. The Sky have been the least lucrative team in the league so far this season, going 5-13 against-the-spread (8-10 straight-up) through their first 18 games. However, Chicago has paid off for OVER bettors, as they sit at 13-5 OU on the season. The Sky fell 75-64 to Washington last time out, with Jia Perkins scoring a team-high 14 points and Candice Dupree tossing in 10 points.

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